Milestones of Science Books

HOPPE-SEYLER, Felix.

Beiträge zur Kenntniss der Constitution des Blutes. I. Über die Oxydation im lebenden Blute. pp. 133-150.

Berlin: August Hirschwald, 1866.

1st Edition. Hardcover. Very Good. Item #002763

In: Medicinisch-chemische Untersuchungen aus dem Laboratorium für angewandte Chemie zu Tübingen. Berlin: August Hirschwald, 1866-1868. Heft 1-3. 8vo (222 x 152 mm). vi, 167 [1]; iv, 169-300, iv, 301-439 [1] pp., including 3 folding lithographic plates. Contemporary half library cloth, spine with gilt-lettering and paper label (head of spine frayed, little wear to extremities. Text little browned, light brown spotting and foxing of plates. Provnance: Speyer, Landwirtschaftliche Kreisversuchsstation (round ink stamp and shelf-marks on first title-page). ----
DSB VI, p.505-6. FIRST EDITION. The reversible oxygenation of hemoglobin was first reported here by Felix Hoppe-Seyler, who also coined the name 'hemoglobin'. With the aid of absorption spectra of the blood dye, Hoppe-Seyler was able to show that hemoglobin in the form of oxihemoglobin reversibly binds oxygen in the blood. He recognized in 1866 that the further oxidation takes place in the tissues and not in the blood. Furthermore, he concluded that the toxicity of carbon monoxide and hydrogen sulphide is caused by the displacement of oxygen from oxhemoglobin, since this has a much higher affinity for these substances than for oxygen. This was a finding of enormous toxicological significance. It is also worth mentioning that the names hemoglobin and oxihemoglobin are derived from it. Also included in this volume is Hoppe-Seyler's important paper "Beiträge zur Kenntnis des Blutes des Menschen und der Wirbeltiere (Heft 3, pp. 366-385). - Visit our website for additional images and information.

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